2014 Feb;27(1):71-8. doi: 10.1177/0897190013504957.
It is safe and effective in protecting the liver.
Correspondence: Siegfried Kasper, MD, Professor and Chair, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria ( Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of ViennaDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical SchoolDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian UniversityCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna Preexisting hepatic injury was the most common risk factor by far (59 cases), followed by substance abuse, mostly alcohol (20 cases). It is, however, difficult to attribute liver damage to a specific medication in clinical practice (Genetic metabolic variability is the most significant susceptibility factor in drug-induced liver toxicity. Understanding druginduced liver injury associated with antidepressants and the importance of safety monitoring is essential to optimize outcomes for antidepressant treatment. From 2003 on, measurement of liver enzymes was done at all participating hospitals at a temperature of 37°C. *Other TCAs: amitryptilinoxid, desipramine, dibenzepin, imipramine. Another sinister cause of liver damage and thus elevated liver enzymes is an overload of certain metals in the body. In terms of GOT values, duloxetine and clomipramine performed worst, and again mirtazapine had the least influence on GOT values.
Rare (0.01% to 0.1%): Hepatic failure, jaundice. A total of 27 inpatients showed clinical symptoms, while the majority did not show any. Regarding the low actual number of cases and the significant number of inpatients involved, the CI was calculated employing the exact method rather than one of the approximate methods (Vollset, 1993). The most common clinical symptoms were nausea, fatigue, loss of appetite, and abdominal pain. Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of ViennaDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical SchoolDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian UniversityCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna In patients with mild to moderate hepatic impairment, little drug accumulation has been observed following once …
COVID-19 is an emerging, rapidly evolving situation. Paroxetine, fluoxetine, fluvoxamine, citalopram, mirtazapine and venlafaxine are associated with reversible liver injury upon discontinuation of the agent. The AMSP group published a manuscript on severe ADRs of ADs in the year 2004 (In our study population, up to 0.02% of inpatients receiving long-term therapy with fluoxetine showed elevated liver enzymes. Clozapine and risperidone induced liver damage, and even acute liver failure associated with clozapine has been documented (Our results are to some extent consistent with preexisting findings as summarized in a recent review of antidepressant-induced liver injury published in 2014, which also indicated a greater risk of hepatotoxicity for TCAs and agomelatine and the least potential for DILI with SSRIs (Furthermore, antidepressant-induced liver injury is considered to be dose independent.
Treatment discontinuation impact on long-term (10-years) weight gain and lipid metabolism in first-episode psychosis: results from the PAFIP-10 cohort. 2014 Apr;171(4):404-15. doi: 10.1176/appi.ajp.2013.13050709.Billioti de Gage S, Collin C, Le-Tri T, Pariente A, Bégaud B, Verdoux H, Dray-Spira R, Zureik M.CNS Drugs. Search for other works by this author on: Molecular biology and clinicsHyponatraemia during psychopharmacological treatment: results of a drug surveillance programmeFatal acute fulminant liver failure due to clozapine: a case report and review of clozapine-induced hepatotoxicityAnticonvulsant hypersensitivity syndrome: clinical and laboratory featuresCytochrome P4502C9: an enzyme of major importance in human drug metabolismR: A language and environment for statistical computing. Drs Grohmann and Toto are involved in the project management of AMSP. Nervous: dizziness, vertigo.
Clinical Correlates and Outcome of Major Depressive Disorder and Comorbid Migraine: A Report of the European Group for the Study of Resistant Depression Search for other works by this author on: