This may be administered using a combination of dosage forms, e.g. White to off white, soft, homogeneous, cream likeFor the local symptomatic relief of pain and inflammation in:- trauma of the tendons, ligaments, muscles and joints, eg due to sprains, strains and bruisesIt is recommended that the treatment be reviewed after 14 days in these indications. Continue typing to refine. Voltarol gels are suitable for adults and teenagers aged 14 years and over. Discontinuation therapy is usually followed by recovery to the pre-treatment state.
The risk of GI bleeding, ulceration or perforation is higher with increasing NSAID doses including diclofenac, and in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation.The elderly have increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding and perforation which may be fatal (see section 4.2 Posology and method of administration).To reduce the risk of GI toxicity in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation, and in the elderly, the treatment should be initiated and maintained at the lowest effective dose. There is a limited clinical trial experience of the use of diclofenac in JRA/JIA paediatric patients. (12.5mg and 25mg suppositories only)Absorption is rapid; although the rate of absorption is slower than from enteric-coated tablets administered orally. before or after major surgery (see section 4.3 Contraindications). After the administration of 50mg suppositories, peak plasma concentrations are attained on average within 1 hour, but maximum concentrations per dose unit are about two thirds of those reached after administration of enteric-coated tablets (1.95 ± 0.8µg/ml (1.9µg/ml ≡ 5.9µmol/l)).As with oral preparations the AUC is approximately a half of the value obtained from a parenteral dose.Pharmacokinetic behaviour does not change on repeated administration. The use of activated charcoal should be considered, especially within a short time (within one hour) of ingestion of a toxic dose.
In the case of significant poisoning acute renal failure and liver damage are possible.Patients should be treated symptomatically as required.