Ann Intern Med. Arch Intern Med. statin, antimicrobial, antibiotic, antifungal, drug interaction. 2011;138(7):2246–59.Kim KY, Frey RJ, Epplen K, Foruhari F. Interaction between warfarin and nafcillin: case report and review of the literature. Harmful effects in older patients include muscle, kidney damage, researchers sayMONDAY, June 17 (HealthDay News) -- Doctors should avoid ordering certain "These drugs do interact and cause difficulties for patients," said lead researcher Dr. Amit Garg, a professor in the department of epidemiology and biostatistics at the University of Western Ontario in London, Ontario.These adverse reactions are rare, Garg added. Effect of fluconazole on plasma fluvastatin and pravastatin concentrations. Rifampin and rifabutin drug interactions. Introduction The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). 2.3. 2003;59(1):51–6.Corsini A, Ceska R. Drug–drug interactions with statins: will pitavastatin overcome the statins’ Achilles’ heel? J Antimicrob Chemother. FDA adverse event reports on statin-associated rhabdomyolysis. 1999;161(10):1266–7.Stone NJ, Robinson J, Lichtenstein AH, Merz CNB, Lloyd-Jones DM, et al. Lowering cholesterol isn't the only benefit associated with statins. Clin Pharmacol Drug Dev. Eur J Clin Pharmacol. You can also search for this author in
2002;46(1):49–53.Neuvonen PJ, Jalava K-M. Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid. Antimicrobial use has also increased in recent years, and various efforts have been implemented to ensure appropriate use of antimicrobials. In 2012, the US Food and Drug Administration strengthened warning labels for statins and dose adjustments related to drug-drug interactions. Statin-related adverse effects are often dose-dependent; therefore, patients may be at increased risk. Antimicrobial use has also increased in recent years, and various efforts have been implemented to ensure appropriate use of antimicrobials. 1998;64(2):177–82.Siedlik PH, Olson SC, Yang BB, Stern RH. Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin.
2007;14(1):30–40.Kantola T, Backman JT, Niemi M, Kivistö KT, Neuvonen PJ. years however, interest returned to the inherent antimicrobial effects of statins (Jerwood & Cohen, 2008).
J Am Coll Cardiol. East Hanover: Novartis; 2012.Sporanox [package insert]. 1999;39(5):501–4.Cooper KJ, Martin PD, Dane AL, Warwick MJ, Raza A, Schneck DW.
Pharmacotherapy. Case Rep Nephrol. "Given the frequency at which statins are prescribed (atorvastatin is currently the most commonly prescribed drug in Canada), and the high rate of co-prescription seen in our study and in other jurisdictions, this preventable drug-drug interaction remains clinically important," Garg's team said.To prevent the interaction, the researchers suggested:They also suggested that clinicians be aware of the most commonly observed drug interactions with statins, noting that free online drug interaction programs exist.The researchers estimated 79 people need to be treated with both clarithromycin or erythromycin and the statins to cause acute kidney injury to one patient.They estimate that 399 people need to be treated by the drug combination to cause one death, from any cause. Ann Pharmacother. Clin Pharmacol Ther. "Co-prescription of either clarithromycin or erythromycin with atorvastatin, simvastatin, or lovastatin was associated with an increased risk of hospital admission with rhabdomyolysis, acute kidney injury and all cause mortality," the study's authors concluded.Rhabdomyolysis occurs when the body can't metabolize proteins released from the muscles and they enter the bloodstream.Symptoms of rhabdomyolysis include muscle pain, weakness, tenderness, fever, dark urine, nausea, and vomiting. Circulation.
Eur J Clin Pharmacol. Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4. Figure 1. 2015;2015:761393.Savant R. Rhabdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin. Need to stay updated on coronavirus news in Texas? 1998;63(3):332–41.Yamazaki T, Desai A, Goldwater R, Han D, Lasseter KC, Howieson C, et al. 1996;60(1):54–61.Neuvonen PJ, Kantola T, Kivist KT. Available at: Erythromycin [package insert]. In addition to statin utilization increasing in recent years, there is greater emphasis on using moderate to high-intensity statin doses.
Effect of a single-dose rifampin on the pharmacokinetics of pitavastatin in healthy volunteers. 1995 [cited 2017 Jun 9];13(2):105–22.Marzolini C, Paus E, Buclin T, Kim RB.